文章：

外周T细胞淋巴瘤的一线治疗：一项关于自体干细胞移植作用研究的扩展及长期随访

First-line therapy of peripheral T-cell lymphoma: extension and long-term follow-up of a study investigating the role of autologous stem cell transplantation

原文发布日期：2016-07-29

DOI: 10.1038/bcj.2016.63

类型: Original Article

开放获取: 是

英文摘要：

Current guidelines recommend consolidation with autologous stem cell transplantation (autoSCT) after induction chemotherapy for most patients with peripheral T-cell lymphoma (PTCL). This assumption is based on five prospective phase II studies, three of which included <50 patients with limited follow-up. Here we present the final analysis of the prospective German study. The treatment regimen consisted of four to six cycles of CHOP chemotherapy followed by mobilizing therapy and stem cell collection. Patients in complete remission (CR) or partial remission (PR) underwent myeloablative chemo(radio)therapy and autoSCT. From January 2001 to July 2010, 111 patients were enrolled in the study. The main subgroups were PTCL not specified (n=42) and angioimmunoblastic T-cell lymphoma (n=37). Seventy-five (68%) of the 111 patients received transplantation. The main reason for not receiving autoSCT was progressive disease. In an intent-to-treat analysis, the complete response rate after myeloablative therapy was 59%. The estimated 5-year overall survival, disease-free survival and progression-free survival rates were 44%, 54% and 39%, respectively. The results of this study confirm that upfront autoSCT can result in long-term remissions in patients with all major subtypes of PTCL and therefore should be part of first-line therapy whenever possible.

摘要翻译： 

当前指南建议，大多数外周T细胞淋巴瘤患者在诱导化疗后采用自体干细胞移植进行巩固治疗。这一方案基于五项前瞻性II期研究，其中三项研究纳入的患者不足50例且随访时间有限。本文呈现德国前瞻性研究的最终分析结果。治疗方案包括4至6个周期的CHOP化疗，随后进行动员治疗和干细胞采集。达到完全缓解或部分缓解的患者接受清髓性化学（放射）治疗及自体干细胞移植。2001年1月至2010年7月期间，共有111例患者入组本研究。主要亚型包括非特指型外周T细胞淋巴瘤（42例）和血管免疫母细胞性T细胞淋巴瘤（37例）。111例患者中有75例（68%）接受了移植治疗。未接受自体干细胞移植的主要原因是疾病进展。意向性治疗分析显示，清髓性治疗后完全缓解率达59%。预计5年总生存率、无病生存率和无进展生存率分别为44%、54%和39%。本研究结果证实，前期自体干细胞移植可使所有主要亚型的外周T细胞淋巴瘤患者获得长期缓解，因此应尽可能作为一线治疗的组成部分。

原文链接：

First-line therapy of peripheral T-cell lymphoma: extension and long-term follow-up of a study investigating the role of autologous stem cell transplantation