文章：

淋巴瘤和骨髓瘤与自身免疫性疾病的家族关联

Familial associations of lymphoma and myeloma with autoimmune diseases

原文发布日期：2017-01-06

DOI: 10.1038/bcj.2016.123

类型: Original Article

开放获取: 是

英文摘要：

Many B-cell neoplasms are associated with autoimmune diseases (AIDs) but most evidence is based on a personal rather than a family history of AIDs. Here we calculated risks for non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL) and multiple myeloma (MM) when family members were diagnosed with any of 44 different AIDs, or, independently, risk for AIDs when family members were diagnosed with a neoplasm. A total of 64 418 neoplasms and 531 155 AIDs were identified from Swedish nationwide health care records. NHL was associated with a family history of five AIDs, all increasing the risk, HL was associated with one AID increasing and three AIDs decreasing the risk while MM had no association. A family history of NHL was associated with eight, HL with seven and MM with seven different AIDs, nine increasing and 13 decreasing the risk. The present family data on B-cell neoplasms and AIDs show an approximately equal number of associations for risk increase and risk decrease, suggesting that inherited genes or gene-environment interactions may increase the risk or be protective. These results differed from published data on personal history of AID, which only report increased risks, often vastly higher and for different AIDs compared with the present data.

摘要翻译： 

许多B细胞肿瘤与自身免疫性疾病相关，但大多数证据基于个体自身病史而非家族史。本研究通过分析瑞典全国医疗记录中的64,418例肿瘤和531,155例自身免疫性疾病数据，计算了当家族成员确诊44种自身免疫性疾病中任意一种时，非霍奇金淋巴瘤、霍奇金淋巴瘤和多发性骨髓瘤的发病风险；以及当家族成员确诊淋巴瘤时，自身免疫性疾病的发病风险。结果显示：非霍奇金淋巴瘤与5种家族性自身免疫性疾病相关（均增加风险），霍奇金淋巴瘤与1种风险升高及3种风险降低的自身免疫性疾病相关，而多发性骨髓瘤未见关联。有非霍奇金淋巴瘤家族史者与8种自身免疫性疾病相关，霍奇金淋巴瘤与7种相关，多发性骨髓瘤与7种相关——其中9种增加风险，13种降低风险。本研究关于B细胞肿瘤与自身免疫性疾病的家族史数据显示风险升高与降低的关联数量大致相当，提示遗传基因或基因-环境相互作用可能具有双重作用：既可能增加风险，也可能产生保护效应。这些结果与既往基于自身病史的研究数据存在差异——后者仅报告风险升高（且增幅通常远高于本研究），涉及的自身免疫性疾病种类也与本研究不同。

原文链接：

Familial associations of lymphoma and myeloma with autoimmune diseases