文章：

多发性骨髓瘤细胞遗传学结果在临床实践中的解读

Interpretation of cytogenetic results in multiple myeloma for clinical practice

原文发布日期：2015-10-30

DOI: 10.1038/bcj.2015.92

类型: Review

开放获取: 是

英文摘要：

The interpretation of cytogenetic abnormalities in multiple myeloma (MM) is often a challenging task. MM is characterized by several cytogenetic abnormalities that occur at various time points in the disease course. The interpretation of cytogenetic results in MM is complicated by the number and complexity of the abnormalities, the methods used to detect them and the disease stage at which they are detected. Specific cytogenetic abnormalities affect clinical presentation, progression of smoldering multiple myeloma (SMM) to MM, prognosis of MM and management strategies. The goal of this paper is to provide a review of how MM is classified into specific subtypes based on primary cytogenetic abnormalities and to provide a concise overview of how to interpret cytogenetic abnormalities based on the disease stage to aid clinical practice and patient management.

摘要翻译： 

多发性骨髓瘤(MM)中细胞遗传学异常的解释通常是一项具有挑战性的任务。该疾病的特点是在病程不同时间点出现多种细胞遗传学异常。由于异常的数量和复杂性、检测方法以及发现异常时的疾病阶段等因素，使得MM细胞遗传学结果的解读变得复杂。特定细胞遗传学异常会影响临床表现、冒烟型多发性骨髓瘤(SMM)向MM的进展、MM的预后及治疗策略。本文旨在综述如何根据原发性细胞遗传学异常将MM划分为特定亚型，并简要概述如何依据疾病阶段解读细胞遗传学异常，从而为临床实践和患者管理提供指导。

原文链接：

Interpretation of cytogenetic results in multiple myeloma for clinical practice