文章：

骨髓瘤发生中的细胞免疫系统：NK细胞与T细胞在多发性骨髓瘤发展中的作用及其在免疫治疗中的应用

The cellular immune system in myelomagenesis: NK cells and T cells in the development of MM and their uses in immunotherapies

原文发布日期：2015-04-17

DOI: 10.1038/bcj.2015.32

类型: Review

开放获取: 是

英文摘要：

As vast strides are being made in the management and treatment of multiple myeloma (MM), recent interests are increasingly focusing on understanding the development of the disease. The knowledge that MM develops exclusively from a protracted phase of monoclonal gammopathy of undetermined significance provides an opportunity to study tumor evolution in this process. Although the immune system has been implicated in the development of MM, the scientific literature on the role and status of various immune components in this process is broad and sometimes contradictory. Accordingly, we present a review of cellular immune subsets in myelomagenesis. We summarize the current literature on the quantitative and functional profiles of natural killer cells and T-cells, including conventional T-cells, natural killer T-cells, γδ T-cells and regulatory T-cells, in myelomagenesis. Our goal is to provide an overview of the status and function of these immune cells in both the peripheral blood and the bone marrow during myelomagenesis. This provides a better understanding of the nature of the immune system in tumor evolution, the knowledge of which is especially significant considering that immunotherapies are increasingly being explored in the treatment of both MM and its precursor conditions.

摘要翻译： 

随着多发性骨髓瘤（MM）治疗与管理取得巨大进展，近期研究兴趣日益聚焦于理解该疾病的发展过程。已知MM完全由意义未明的单克隆丙种球蛋白病这一漫长阶段发展而来，这为研究该过程中的肿瘤演化提供了契机。尽管免疫系统已被证实参与MM的发展，但关于各种免疫成分在此过程中作用与状态的科学文献内容广泛且时有矛盾。为此，本文对骨髓瘤生成过程中的细胞免疫亚群进行综述。我们汇总了现有文献中关于自然杀伤细胞和T细胞（包括常规T细胞、自然杀伤T细胞、γδ T细胞及调节性T细胞）在骨髓瘤生成过程中的数量与功能特征研究。我们的目标是系统阐述这些免疫细胞在骨髓瘤发生过程中，于外周血和骨髓内的状态与功能。这有助于更深入理解免疫系统在肿瘤演化中的本质特性，鉴于免疫疗法日益广泛应用于MM及其前驱状态的治疗，相关认知显得尤为重要。

原文链接：

The cellular immune system in myelomagenesis: NK cells and T cells in the development of MM and their uses in immunotherapies