文章：

诱导多能干细胞在血液学中的应用

Induced pluripotent stem cells in hematology: current and future applications

原文发布日期：2014-05-09

DOI: 10.1038/bcj.2014.30

类型: Review

开放获取: 是

英文摘要：

Reprogramming somatic cells into induced pluripotent stem (iPS) cells is nowadays approaching effectiveness and clinical grade. Potential uses of this technology include predictive toxicology, drug screening, pathogenetic studies and transplantation. Here, we review the basis of current iPS cell technology and potential applications in hematology, ranging from disease modeling of congenital and acquired hemopathies to hematopoietic stem and other blood cell transplantation.

摘要翻译： 

将体细胞重编程为诱导多能干细胞（iPS细胞）的技术目前正逐步实现高效性与临床级应用。该技术的潜在用途涵盖预测毒理学、药物筛选、发病机制研究及移植治疗。本文综述了当前iPS细胞技术的基础原理及其在血液学中的潜在应用，包括从先天性/获得性血液病的疾病模型构建到造血干细胞与其他血细胞移植的研究领域。

原文链接：

Induced pluripotent stem cells in hematology: current and future applications