文章：

表观遗传学在多发性骨髓瘤生物学中的作用

The role of epigenetics in the biology of multiple myeloma

原文发布日期：2014-05-02

DOI: 10.1038/bcj.2014.29

类型: Review

开放获取: 是

英文摘要：

Several recent studies have highlighted the biological complexity of multiple myeloma (MM) that arises as a result of several disrupted cancer pathways. Apart from the central role of genetic abnormalities, epigenetic aberrations have also been shown to be important players in the development of MM, and a lot of research during the past decades has focused on the ways DNA methylation, histone modifications and noncoding RNAs contribute to the pathobiology of MM. This has led to, apart from better understanding of the disease biology, the development of epigenetic drugs, such as histone deacetylase inhibitors that are already used in clinical trials in MM with promising results. This review will present the role of epigenetic abnormalities in MM and how these can affect specific pathways, and focus on the potential of novel ‘epidrugs’ as future treatment modalities for MM.

摘要翻译： 

最近几项研究揭示了多发性骨髓瘤（MM）因多条癌症通路失调而产生的生物学复杂性。除遗传异常的核心作用外，表观遗传畸变也被证明在MM发展中扮演重要角色。过去数十年的研究大量集中于DNA甲基化、组蛋白修饰及非编码RNA对MM病理生物学的影响。这不仅深化了对疾病生物学的理解，更推动了表观遗传药物的研发——例如组蛋白去乙酰化酶抑制剂已在MM临床试验中取得可喜成果。本文综述将阐述表观遗传异常在MM中的作用及其对特定通路的影响，并重点探讨新型表观药物作为未来MM治疗模式的潜力。

原文链接：

The role of epigenetics in the biology of multiple myeloma