文章：

Twist蛋白在造血细胞和血液恶性肿瘤中的新作用

The emerging role of Twist proteins in hematopoietic cells and hematological malignancies

原文发布日期：2014-04-25

DOI: 10.1038/bcj.2014.22

类型: Review

开放获取: 是

英文摘要：

Twist1 and Twist2 (Twist1–2) are two transcription factors, members of the basic helix-loop-helix family, that have been well established as master transcriptional regulators of embryogenesis and developmental programs of mesenchymal cell lineages. Their role in oncogenesis in epithelium-derived cancer and in epithelial-to-mesenchymal transition has also been thoroughly characterized. Recently, emerging evidence also suggests a key role for Twist1–2 in the function and development of hematopoietic cells, as well as in survival and development of numerous hematological malignancies. In this review, we summarize the latest data that depict the role of Twist1–2 in monocytes, T cells and B lymphocyte activation, and in associated hematological malignancies.

摘要翻译： 

Twist1与Twist2（简称Twist1–2）是碱性螺旋-环-螺旋家族的两个转录因子，已被确认为间充质细胞谱系胚胎发育过程的核心转录调控因子。这两种因子在上皮源性肿瘤的癌变过程及上皮-间质转化中的作用也已得到充分阐释。最新研究还表明，Twist1–2在造血细胞的功能发育过程中发挥关键作用，并与多种血液系统恶性肿瘤的存活及发展密切相关。本文综述了最新研究数据，旨在阐述Twist1–2在单核细胞、T细胞及B淋巴细胞活化过程中的作用，及其在相关血液系统恶性肿瘤中的调控机制。

原文链接：

The emerging role of Twist proteins in hematopoietic cells and hematological malignancies