文章：

骨形态发生蛋白9通过ALK2信号传导抑制骨髓瘤细胞生长，但被内啡肽抑制

Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin

原文发布日期：2014-03-21

DOI: 10.1038/bcj.2014.16

类型: Original Article

开放获取: 是

英文摘要：

Multiple myeloma is a malignancy of plasma cells predominantly located in the bone marrow. A number of bone morphogenetic proteins (BMPs) induce apoptosis in myeloma cells in vitro, and with this study we add BMP-9 to the list. BMP-9 has been found in human serum at concentrations that inhibit cancer cell growth in vitro. We here show that the level of BMP-9 in serum was elevated in myeloma patients (median 176 pg/ml, range 8–809) compared with healthy controls (median 110 pg/ml, range 8–359). BMP-9 was also present in the bone marrow and was able to induce apoptosis in 4 out of 11 primary myeloma cell samples by signaling through ALK2. BMP-9-induced apoptosis in myeloma cells was associated with c-MYC downregulation. The effects of BMP-9 were counteracted by membrane-bound (CD105) or soluble endoglin present in the bone marrow microenvironment, suggesting a mechanism for how myeloma cells can evade the tumor suppressing activity of BMP-9 in multiple myeloma.

摘要翻译： 

多发性骨髓瘤是一种主要位于骨髓中的浆细胞恶性肿瘤。多种骨形态发生蛋白（BMPs）在体外可诱导骨髓瘤细胞凋亡，本研究将BMP-9纳入该列表。研究发现人血清中BMP-9的浓度达到可在体外抑制癌细胞生长的水平。本研究显示，与健康对照组（中位数110 pg/ml，范围8–359）相比，骨髓瘤患者血清中BMP-9水平升高（中位数176 pg/ml，范围8–809）。BMP-9同样存在于骨髓中，并能通过ALK2信号传导在11个原代骨髓瘤细胞样本中的4个诱导凋亡。BMP-9诱导的骨髓瘤细胞凋亡与c-MYC下调相关。BMP-9的效应被骨髓微环境中存在的膜结合型（CD105）或可溶性内皮糖蛋白所抵消，这揭示了多发性骨髓瘤中肿瘤细胞如何逃逸BMP-9肿瘤抑制活性的机制。

原文链接：

Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin