文章：

老年急性髓性白血病患者核型亚组的发病率和预后意义：瑞典基于人群的经验

Incidence and prognostic significance of karyotypic subgroups in older patients with acute myeloid leukemia: the Swedish population-based experience

原文发布日期：2014-02-28

DOI: 10.1038/bcj.2014.10

类型: Original Article

开放获取: 是

英文摘要：

The Swedish population-based acute myeloid leukemia registry contains data from 3251 patients (excluding acute promyelocytic leukemia) diagnosed between 1997 and 2006. Informative cytogenetic data from 1893 patients were retrospectively added, including 1054 patients aged between 60 and 79 years. Clonal abnormalities were found in 57% of the informative karyotypes. Karyotypic patterns differed by age: t(8;21), inv(16) and t(11q23) were more common in younger patients, whereas loss of 5q, 7q and 17p, monosomal karyotype (MK) and complex karyotypes were more common in older patients. Loss of 5q, 7q and 17p often occurred together within MK. Patients with ⩾5 chromosome abnormalities had worse overall survival than those with fewer abnormalities or normal karyotype in all age groups. Loss of 5q, 7q and/or 17p had, in contrast to MK, a further negative impact on survival. Multivariable Cox regression analyses on risk factors in patients <80 years with cytogenetic abnormalities and intensive treatment revealed that age and performance status had the most significant impact on survival (both P<0.001), followed by sex (P=0.0135) and a karyotype including −7/del(7q) (P=0.048).

摘要翻译： 

瑞典基于人口的急性髓系白血病登记处收录了1997年至2006年间确诊的3251例患者（不包括急性早幼粒细胞白血病）数据。回顾性补充了1893例患者的有效细胞遗传学数据，其中1054例患者年龄在60至79岁之间。在57%的有效核型中发现了克隆性异常。核型模式随年龄差异显著：t(8;21)、inv(16)和t(11q23)在年轻患者中更为常见，而5q、7q和17p缺失、单染色体核型（MK）及复杂核型在老年患者中更为常见。5q、7q和17p缺失常共同出现在单染色体核型中。在所有年龄组中，具有≥5条染色体异常的患者总生存期较异常较少或核型正常者更差。与单染色体核型不同，5q、7q和/或17p缺失对生存率具有进一步的负面影响。对80岁以下存在细胞遗传学异常且接受强化治疗的患者进行多变量Cox回归分析显示，年龄和体能状态对生存率的影响最为显著（均P<0.001），其次是性别（P=0.0135）和包含-7/del(7q)的核型（P=0.048）。

原文链接：

Incidence and prognostic significance of karyotypic subgroups in older patients with acute myeloid leukemia: the Swedish population-based experience