文章：

新一代测序分析在血液恶性肿瘤中的经验教训

Lessons from next-generation sequencing analysis in hematological malignancies

原文发布日期：2013-07-19

DOI: 10.1038/bcj.2013.26

类型: Review

开放获取: 是

英文摘要：

Next-generation sequencing has led to a revolution in the study of hematological malignancies with a substantial number of publications and discoveries in the last few years. Significant discoveries associated with disease diagnosis, risk stratification, clonal evolution and therapeutic intervention have been generated by this powerful technology. As part of the post-genomic era, sequencing analysis will likely become part of routine clinical testing and the challenge will ultimately be successfully transitioning from gene discovery to preventive and therapeutic intervention as part of individualized medicine strategies. In this report, we review recent advances in the understanding of hematological malignancies derived through genome-wide sequence analysis.

摘要翻译： 

新一代测序技术引领了血液系统恶性肿瘤研究领域的革命，近几年来相关出版物和重大发现层出不穷。这项强大技术推动了疾病诊断、风险分层、克隆进化及治疗干预等方面的重大突破。作为后基因组时代的重要组成部分，测序分析有望成为常规临床检测的一环，而核心挑战将是如何成功实现从基因发现到预防性与治疗性干预的转化，并将其纳入个体化医疗策略。本报告综述了通过全基因组序列分析在血液系统恶性肿瘤认知方面取得的最新进展。

原文链接：

Lessons from next-generation sequencing analysis in hematological malignancies