文章：

多发性骨髓瘤和Waldenstrom巨球蛋白血症患者双磷酸盐相关性颌骨骨坏死的演变：一项回顾性多中心研究

Evolution of bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma and Waldenstrom's macroglobulinemia: a retrospective multicentric study

原文发布日期：2012-03-23

DOI: 10.1038/bcj.2012.9

类型: Original Article

开放获取: 是

英文摘要：

Bisphosphonates (BPs) are used intravenously to treat cancer-related conditions for the prevention of pathological fractures. Osteonecrosis of the jaw (BRONJ) is a rare complication reported in 4–15% of patients. We studied, retrospectively, 55 patients with multiple myeloma or Waldenstrom's macroglobulinemia followed up from different haematological departments who developed BRONJ. All patients were treated with BPs for bone lesions and/or fractures. The most common trigger for BRONJ was dental alveolar surgery. After a median observation of 26 months, no death caused by BRONJ complication was reported. In all, 51 patients were treated with antibiotic therapy, and in 6 patients, this was performed in association with surgical debridement of necrotic bone, in 16 with hyperbaric O2 therapy/ozonotherapy and curettage and in 12 with sequestrectomy and O2/hyperbaric therapy. Complete response was observed in 20 cases, partial response in 21, unchanged in 9 and worsening in 3. The association of surgical treatment with antibiotic therapy seems to be more effective in eradicating the necrotic bone than antibiotic treatment alone. O2 hyperbaric/ozonotherapy is a very effective treatment. The cumulative dosage of BPs is important for the evolution of BRONJ. Because the most common trigger for BRONJ was dental extractions, all patients, before BP treatment, must achieve an optimal periodontal health.

摘要翻译： 

准确的淋巴瘤诊断、预后和治疗仍需额外的标志物。我们在一个涵盖所有主要B细胞非霍奇金淋巴瘤（NHL）类型的大型系列中，探讨了微小RNA（miRNA）表达的潜在意义。所得数据还用于识别伯基特淋巴瘤（BL）与弥漫大B细胞淋巴瘤（DLBCL）样本中差异表达的miRNA。将147例NHL样本和15例对照样本在含470条人类miRNA探针的单色人miRNA平台上进行杂交。每种淋巴瘤类型均与整个NHL系列进行比较；BL还与DLBCL直接比较。随后，利用定量逆转录-聚合酶链反应，在28例BL和43例DLBCL的常规处理新系列中对43条预选miRNA进行分析。128条miRNA的签名可表征淋巴瘤肿瘤，反映淋巴瘤类型、细胞来源和/或特定癌基因改变。BL与DLBCL的比较分析获得19条差异表达miRNA，并在第二组71例石蜡包埋样本中得到验证。本研究发现的差异表达miRNA集合扩展了淋巴瘤诊断的潜在诊断标志物范围，尤其在需要鉴别BL与DLBCL时。

原文链接：

Evolution of bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma and Waldenstrom's macroglobulinemia: a retrospective multicentric study