文章：

造血干细胞生态位的拉锯战：骨髓瘤浆细胞会竞争HSC生态位吗？

Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche?

原文发布日期：2012-09-14

DOI: 10.1038/bcj.2012.38

类型: Review

开放获取: 是

英文摘要：

In the adult mammal, normal haematopoiesis occurs predominantly in the bone marrow, where primitive haematopoietic stem cells (HSC) and their progeny reside in specialised microenvironments. The bone marrow microenvironment contains specific anatomical areas (termed niches) that are highly specialised for the development of certain blood cell types, for example HSCs. The HSC niche provides important cell–cell interactions and signalling molecules that regulate HSC self-renewal and differentiation processes. These same signals and interactions are also important in the progression of haematological malignancies, such as multiple myeloma (MM). This review provides an overview of the bone marrow microenvironment and its involvement in normal, physiological HSC maintenance and plasma cell growth throughout MM disease progression.

摘要翻译： 

在成年哺乳动物体内，正常造血主要发生在骨髓中，原始造血干细胞及其后代定居于特化的微环境内。骨髓微环境包含特定解剖区域（称为 niches），这些区域对特定血细胞类型（如造血干细胞）的发育具有高度特异性。造血干细胞龛通过重要的细胞间相互作用和信号分子，调控干细胞的自我更新与分化过程。这些相同的信号与相互作用在多发性骨髓瘤等血液恶性肿瘤的进展中也发挥着关键作用。本综述概述了骨髓微环境的结构特征，并探讨其在生理状态下维持造血干细胞功能、以及在多发性骨髓瘤疾病进展过程中影响浆细胞生长的作用机制。

原文链接：

Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche?