文章：

细胞外囊泡在癌症中的作用

The role of extracellular vesicles in cancer

原文发布日期：2023-04-13

DOI: 10.1016/j.cell.2023.03.010

类型: Review

开放获取: 是

英文摘要：

Intercellular communication is a key feature of cancer progression and metastasis. Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent studies have identified EVs as key mediators of cell-cell communication via packaging and transfer of bioactive constituents to impact the biology and function of cancer cells and cells of the tumor microenvironment. Here, we review recent advances in understanding the functional contribution of EVs to cancer progression and metastasis, as cancer biomarkers, and the development of cancer therapeutics.

摘要翻译： 

细胞间通讯是癌症进展和转移的关键特征。所有细胞（包括癌细胞）均会生成细胞外囊泡。近期研究表明，细胞外囊泡通过包装并传递生物活性成分，影响癌细胞及肿瘤微环境中细胞的生物学特性与功能，成为细胞间通讯的关键介质。本文综述了细胞外囊泡在癌症进展和转移中的功能作用、作为癌症生物标志物的应用，以及癌症治疗药物开发方面的最新进展。

原文链接：

The role of extracellular vesicles in cancer