The uptake and metabolism of nutrients support fundamental cellular process from bioenergetics to biomass production and cell fate regulation. While many studies of cell metabolism focus on cancer cells, the principles of metabolism elucidated in cancer cells apply to a wide range of mammalian cells. The goal of this review is to discuss how the field of cancer metabolism provides a framework for revealing principles of cell metabolism and for dissecting the metabolic networks that allow cells to meet their specific demands. Understanding context-specific metabolic preferences and liabilities will unlock new approaches to target cancer cells to improve patient care.
营养物质的摄取与代谢支撑着从生物能量学到生物质生成乃至细胞命运调控等基础细胞过程。尽管众多细胞代谢研究聚焦于癌细胞，但在癌细胞中阐明的代谢原理同样适用于多种哺乳动物细胞。本综述旨在探讨癌症代谢领域如何为揭示细胞代谢规律、解析细胞满足特定需求的代谢网络提供理论框架。理解不同生理背景下细胞的代谢偏好与脆弱性，将开辟靶向癌细胞的新途径，从而改善患者治疗效果。
肿瘤(癌症)患者之家