文章：

精准肿瘤学的下一个前沿：蛋白质基因组学助力癌症诊断与治疗

The next horizon in precision oncology: Proteogenomics to inform cancer diagnosis and treatment

原文发布日期：2021-04-01

DOI: 10.1016/j.cell.2021.02.055

类型: Perspective

开放获取: 是

英文摘要：

When it comes to precision oncology, proteogenomics may provide better prospects to the clinical characterization of tumors, help make a more accurate diagnosis of cancer, and improve treatment for patients with cancer. This perspective describes the significant contributions of The Cancer Genome Atlas and the Clinical Proteomic Tumor Analysis Consortium to precision oncology and makes the case that proteogenomics needs to be fully integrated into clinical trials and patient care in order for precision oncology to deliver the right cancer treatment to the right patient at the right dose and at the right time.

摘要翻译： 

在精准肿瘤学领域，蛋白质基因组学有望为肿瘤临床特征解析提供更优前景，助力实现更精准的癌症诊断，并改善癌症患者的治疗方案。本文概述了癌症基因组图谱和临床蛋白质组肿瘤分析联盟对精准肿瘤学的重要贡献，并指出必须将蛋白质基因组学全面整合到临床试验与患者诊疗中，才能使精准肿瘤学实现针对正确患者、正确剂量和正确时机的癌症治疗。

原文链接：

The next horizon in precision oncology: Proteogenomics to inform cancer diagnosis and treatment