文章：

癌症靶点的拓展宇宙

An expanded universe of cancer targets

原文发布日期：2021-03-04

DOI: 10.1016/j.cell.2021.02.020

类型:  Perspective

开放获取: 是

英文摘要：

The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles remains mysterious, and many cancer features transcend their genomes. Consequently, tumor genomic characterization does not influence therapy for most patients. Approaches to understand the function and circuitry of cancer genes provide complementary approaches to elucidate both oncogene and non-oncogene dependencies. Emerging work indicates that the diversity of therapeutic targets engendered by non-oncogene dependencies is much larger than the list of recurrently mutated genes. Here we describe a framework for this expanded list of cancer targets, providing novel opportunities for clinical translation.

摘要翻译： 

对癌症基因组的特征解析揭示了不同肿瘤中体细胞突变基因的特性，改变了我们对癌症生物学的理解，并推动了治疗策略的定制化发展。然而，大多数癌症等位基因的功能仍不明确，且许多癌症特征已超越基因组范畴。因此，肿瘤基因组特征分析尚未对大多数患者的治疗产生实质影响。通过研究癌症基因的功能和环路网络，我们可以采取互补性方法阐明癌基因依赖性与非癌基因依赖性。最新研究表明，由非癌基因依赖性产生的治疗靶点多样性远超过反复突变基因列表。在此我们提出一个扩展版癌症靶点框架，为临床转化提供新的机遇。

原文链接：

An expanded universe of cancer targets