文章：

持续存在的癌细胞：致命的幸存者

Persistent Cancer Cells: The Deadly Survivors

原文发布日期：2020-11-12

DOI: 10.1016/j.cell.2020.10.027

类型: Review

开放获取: 是

英文总结：

Persistent cancer cells are the discrete and usually undetected cells that survive cancer drug treatment and constitute a major cause of treatment failure. These cells are characterized by their slow proliferation, highly flexible energy consumption, adaptation to their microenvironment, and phenotypic plasticity. Mechanisms that underlie their persistence offer highly coveted and sought-after therapeutic targets, and include diverse epigenetic, transcriptional, and translational regulatory processes, as well as complex cell-cell interactions. Although the successful clinical targeting of persistent cancer cells remains to be realized, immense progress has been made in understanding their persistence, yielding promising preclinical results.

总结翻译： 

持续存在的癌细胞是在癌症药物治疗后存活下来的离散且通常难以被发现的细胞，是导致治疗失败的主要原因。这些细胞的特征在于其增殖缓慢、能量消耗高度灵活、对微环境的适应性强以及表型可塑性。它们持续存在的机制涵盖了多种表观遗传、转录和翻译调控过程，以及复杂的细胞间相互作用，这些机制为极受关注的治疗靶点提供了方向。尽管针对持续存在癌细胞的临床靶向治疗尚未实现，但在理解其持续存在机制方面已取得重大进展，并获得了有前景的临床前研究成果。

原文链接：

Persistent Cancer Cells: The Deadly Survivors