文章：

内源性DNA损伤作为癌症中基因组不稳定的来源

Endogenous DNA Damage as a Source of Genomic Instability in Cancer

原文发布日期：2017-02-09

DOI: 10.1016/j.cell.2017.01.002

类型: Review

开放获取: 是

英文摘要：

Genome instability, defined as higher than normal rates of mutation, is a double-edged sword. As a source of genetic diversity and natural selection, mutations are beneficial for evolution. On the other hand, genomic instability can have catastrophic consequences for age-related diseases such as cancer. Mutations arise either from inactivation of DNA repair pathways or in a repair-competent background due to genotoxic stress from celluar processes such as transcription and replication that overwhelm high-fidelity DNA repair. Here, we review recent studies that shed light on endogenous sources of mutation and epigenomic features that promote genomic instability during cancer evolution.

摘要翻译： 

基因组不稳定性，即高于正常水平的突变率，是一把双刃剑。作为遗传多样性和自然选择的源泉，突变对进化有益。另一方面，基因组不稳定性可能对癌症等年龄相关疾病产生灾难性后果。突变的产生既可能源于DNA修复途径的失活，也可能发生在具备修复能力的背景下——这是由于转录、复制等细胞过程产生的基因毒性应激，超过了高保真DNA修复的承载能力。本文综述了近期研究，这些研究揭示了癌症演化过程中内源性突变来源以及促进基因组不稳定性的表观基因组特征。

原文链接：

Endogenous DNA Damage as a Source of Genomic Instability in Cancer