文章：

癌症基因组的启示

Lessons from the Cancer Genome

原文发布日期：2013-03-28

DOI: 10.1016/j.cell.2013.03.002

类型: Review

开放获取: 是

英文摘要：

Systematic studies of the cancer genome have exploded in recent years. These studies have revealed scores of new cancer genes, including many in processes not previously known to be causal targets in cancer. The genes affect cell signaling, chromatin, and epigenomic regulation; RNA splicing; protein homeostasis; metabolism; and lineage maturation. Still, cancer genomics is in its infancy. Much work remains to complete the mutational catalog in primary tumors and across the natural history of cancer, to connect recurrent genomic alterations to altered pathways and acquired cellular vulnerabilities, and to use this information to guide the development and application of therapies.

摘要翻译： 

近年来，对癌症基因组的系统性研究呈爆炸式增长。这些研究揭示了大量新的癌症基因，其中许多涉及先前未知的癌症致病靶点过程。这些基因影响着细胞信号传导、染色质与表观基因组调控、RNA剪接、蛋白质稳态、新陈代谢以及细胞谱系成熟。然而，癌症基因组学仍处于初级阶段。仍有许多工作需要完成：完善原发性肿瘤及癌症自然史中的突变目录，将反复出现的基因组改变与异常通路及获得的细胞脆弱性联系起来，并利用这些信息指导疗法的开发与应用。

原文链接：

Lessons from the Cancer Genome