文章：

癌症中的转化生长因子β

TGFβ in Cancer

原文发布日期：2008-07-25

DOI: 10.1016/j.cell.2008.07.001

类型: Review

开放获取: 是

英文摘要：

The transforming growth factor β (TGFβ) signaling pathway is a key player in metazoan biology, and its misregulation can result in tumor development. The regulatory cytokine TGFβ exerts tumor-suppressive effects that cancer cells must elude for malignant evolution. Yet, paradoxically, TGFβ also modulates processes such as cell invasion, immune regulation, and microenvironment modification that cancer cells may exploit to their advantage. Consequently, the output of a TGFβ response is highly contextual throughout development, across different tissues, and also in cancer. The mechanistic basis and clinical relevance of TGFβ's role in cancer is becoming increasingly clear, paving the way for a better understanding of the complexity and therapeutic potential of this pathway.

摘要翻译： 

转化生长因子β（TGFβ）信号通路在后生动物生物学中扮演关键角色，其失调可能导致肿瘤发生。这种调节性细胞因子TGFβ具有肿瘤抑制作用，癌细胞必须逃避这种抑制才能实现恶性演化。然而矛盾的是，TGFβ同时也调控细胞侵袭、免疫调节和微环境修饰等过程，这些过程可能被癌细胞利用以促进其发展。因此，TGFβ反应的作用具有高度情境依赖性，贯穿发育过程、不同组织类型以及癌症发展阶段。TGFβ在癌症中的作用机制基础和临床意义日益明晰，为深入理解该通路的复杂性及治疗潜力奠定了基础。

原文链接：

TGFβ in Cancer